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Higher fluid and lower caloric intakes: associated risk of severe bronchopulmonary dysplasia in ELBW infants

Journal of Perinatology (2024)Cite this article

Subjects

Abstract

Objective

To examine nutritional intake profiles and growth trajectories of extremely low birth weight (ELBW) infants who develop severe bronchopulmonary dysplasia (BPD).

Study design

Case-control study using multiple logistic regression analysis with generalized estimating equations (GEE) to adjust for matching.

Results

Cumulative and mean fluid intakes were higher (p = 0.003) and caloric intakes lower (p < 0.0001) through week two in infants who developed severe BPD (n = 120) versus those without severe BPD (n = 104). Mean caloric intake through week 12 was lower in infants who developed severe BPD (102 ± 10.1 vs. 107 ± 8.5 kcal/kg/day, p < 0.0001). In the logistic regression models, lower mean caloric intake through week 12 was associated with increased risk of developing severe BPD. Linear growth reduced the odds of BPD by ~30% for each Z-score point.

Conclusions

Higher fluid and lower total caloric intakes and reductions in linear growth were independently associated with an increased risk of developing severe BPD in ELBW infants.

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Fig. 1: Closed bars represent cases with severe BPD and open bars represent cases without severe BPD.

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Data availability

The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

No funding was secured for this study.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, RI, USA

    Danielle Kolitz, Lynn Przystac, Richard Tucker, William Oh & Barbara S. Stonestreet

Authors
  1. Danielle Kolitz
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  2. Lynn Przystac
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  3. Richard Tucker
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  4. William Oh
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  5. Barbara S. Stonestreet
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Contributions

Dr. Kolitz conceptualized and designed the study, designed the data collection instruments, collected data, carried out the initial analyses, and drafted the initial manuscript. Lynn Przystac conceptualized and designed the study, designed the data collection instruments, and reviewed and revised the manuscript. Richard Tucker conceptualized and designed the study, designed the data collection instruments, carried out the initial analyses, and reviewed and revised the manuscript. Dr. Oh conceptualized and designed the study and critically reviewed the manuscript for important intellectual content. Dr. Stonestreet conceptualized and designed the study, coordinated, and supervised data collection, and critically reviewed the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Barbara S. Stonestreet.

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Kolitz, D., Przystac, L., Tucker, R. et al. Higher fluid and lower caloric intakes: associated risk of severe bronchopulmonary dysplasia in ELBW infants. J Perinatol (2024). https://doi.org/10.1038/s41372-024-01928-0

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