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Linear growth is associated with successful respiratory support weaning in infants with bronchopulmonary dysplasia

Journal of Perinatology volume 42, pages 544–545 (2022)Cite this article

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Extremely low birth weight (ELBW < 1000 g) and very low birth weight (VLBW—1000–1500 g) infants are surviving in increasing numbers, and bronchopulmonary dysplasia (BPD) is a common morbidity in this population [1]. VLBW infants with BPD are more likely to experience growth failure compared to VLBW infants without BPD [2]. This is likely related to energy requirements for respiratory effort, associated infections, and BPD management techniques that include fluid restriction, diuretics, and systemic corticosteroids [2].

Linear growth in particular, is more closely associated with lean body mass accretion and organ growth [3], and an increase in height velocity is associated with improvement of lung function in infants with BPD [4]. Therefore, an improvement in linear growth in infants with BPD may be associated with improvement in lung growth and repair.

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Fig. 1: Mean change in length Z score grouped by number of respiratory weaning failures.

References

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Authors and Affiliations

  1. Department of Pediatrics, Division of Neonatology, West Virginia University School of Medicine, Morgantown, WV, USA

    Audrey N. Miller, Alicia A. Moise, Mark Polak & Alfred Gest

  2. Department of Pediatrics, West Virginia University School of Medicine, Morgantown, WV, USA

    Lesley Cottrell

  3. Department of Nutrition Services, WVU Medicine, Morgantown, WV, USA

    Kelly Loomis

Authors
  1. Audrey N. Miller
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  2. Alicia A. Moise
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  3. Lesley Cottrell
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  4. Kelly Loomis
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  5. Mark Polak
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  6. Alfred Gest
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Contributions

ANM and AAM contributed to project design, data collection, and interpretation of results, drafting, and revising the paper. KL, LC, MP, and AG contributed to project design, interpreting results, and paper review. All authors give final approval of the version to be published and agree to be accountable for all aspects of the work.

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Correspondence to Audrey N. Miller.

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The authors declare no competing interests.

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This study was approved by the institutional review board at our institution. Reference number 1812377335. The need for consent was waived. This study was performed in accordance with the Declaration of Helsinki.

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Miller, A.N., Moise, A.A., Cottrell, L. et al. Linear growth is associated with successful respiratory support weaning in infants with bronchopulmonary dysplasia. J Perinatol 42, 544–545 (2022). https://doi.org/10.1038/s41372-022-01322-8

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  • DOI: https://doi.org/10.1038/s41372-022-01322-8

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