Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Journal Club
  • Published:

Precision medicine in neonatal hemodynamics: need for prioritization of mechanism of illness and defining population of interest

Journal of Perinatology volume 40, pages 1446–1449 (2020)Cite this article

Subjects

Manuscript citation: Serrano RM, Madison M, Lorant D, Hoyer M, Alexy R. Comparison of ‘post-patent ductus arteriosus syndrome’ in premature infants after surgical ligation vs. percutaneous closure. J Perinatol. 2020;40:324–9.

Retrospective and prospective cohort study.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Probability of inotropes in the postoperative period of PDA ligation.

Notes

  1. The acronym PICO(T) is used as a mnemonic for drafting a focused clinical question. P stands for patient/population; I for intervention/indicator; C for compare/control; O for outcome; and T for time or type of study or question.

References

  1. Serrano RM, Madison M, Lorant D, Hoyer M, Alexy R. Comparison of ‘post-patent ductus arteriosus ligation syndrome’ in premature infants after surgical ligation vs. percutaneous closure. J Perinatol. 2020;40:324-9.

    Article  Google Scholar 

  2. Backes CH, Giesinger RE, Rivera BK, Berman DP, Smith CV, Cua CL, et al. Percutaneous closure of the patent ductus arteriosus in very low weight infants: considerations following US Food and Drug Administration approval of a novel device. J Pediatr. 2019;213:218–21.

    Article  Google Scholar 

  3. Clyman RI, Wickremasinghe A, Merritt TA, Solomon T, McNamara P, Jain A, et al. Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones. J Pediatr. 2014;164:1449–55.

    Article  CAS  Google Scholar 

  4. Harting MT, Blakely ML, Cox CS Jr, Lantin-Hermoso R, Andrassy RJ, Lally KP. Acute hemodynamic decompensation following patent ductus arteriosus ligation in premature infants. J Investig Surg. 2008;21:133–8.

    Article  Google Scholar 

  5. Moin F, Kennedy KA, Moya FR. Risk factors predicting vasopressor use after patent ductus arteriosus ligation. Am J Perinatol. 2003;20:313–20.

    Article  Google Scholar 

  6. Giesinger RE, Bischoff AR, McNamara PJ. Anticipatory perioperative management for patent ductus arteriosus surgery: understanding postligation cardiac syndrome. Congenit Heart Dis. 2019;14:311–6.

    Article  Google Scholar 

  7. Teixeira LS, Shivananda SP, Stephens D, Van Arsdell G, McNamara PJ. Postoperative cardiorespiratory instability following ligation of the preterm ductus arteriosus is related to early need for intervention. J Perinatol. 2008;28:803–10.

    Article  CAS  Google Scholar 

  8. McNamara PJ, Stewart L, Shivananda SP, Stephens D, Sehgal A. Patent ductus arteriosus ligation is associated with impaired left ventricular systolic performance in premature infants weighing less than 1000 g. J Thorac Cardiovasc Surg. 2010;140:150–7.

    Article  Google Scholar 

  9. Abu Hazeem AA, Gillespie MJ, Thun H, Munson D, Schwartz MC, Dori Y, et al. Percutaneous closure of patent ductus arteriosus in small infants with significant lung disease may offer faster recovery of respiratory function when compared to surgical ligation. Catheter Cardiovasc Inter. 2013;82:526–33.

    Google Scholar 

  10. Sathanandam S, Balduf K, Chilakala S, Washington K, Allen K, Knott-Craig C, et al. Role of transcatheter patent ductus arteriosus closure in extremely low birth weight infants. Catheter Cardiovasc Inter. 2019;93:89–96.

    Article  Google Scholar 

  11. Zahn EM, Peck D, Phillips A, Nevin P, Basaker K, Simmons C, et al. Transcatheter closure of patent ductus arteriosus in extremely premature newborns: early results and midterm follow-up. JACC Cardiovasc Inter. 2016;9:2429–37.

    Article  Google Scholar 

  12. Clyman RI, Liebowitz M, Kaempf J, Erdeve O, Bulbul A, Hakansson S, et al. PDA-TOLERATE Trial: an exploratory randomized controlled trial of treatment of moderate-to-large patent ductus arteriosus at 1 week of age. J Pediatr. 2019;205:41–8.

    Article  Google Scholar 

  13. Liebowitz M, Katheria A, Sauberan J, Singh J, Nelson K, Hassinger DC, et al. Lack of equipoise in the PDA-TOLERATE Trial: a comparison of eligible infants enrolled in the trial and those treated outside the trial. J Pediatr. 2019;213:222–6.

    Article  Google Scholar 

Download references

Acknowledgements

The Journal club is a collaboration between the American Academy of Pediatrics-Section of Neonatal Perinatal medicine and the International Society of Evidence- based neonatology (EBNEO.org).

Author information

Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, University of Iowa Stead Family Children’s Hospital, Iowa City, IA, USA

    Adrianne Rahde Bischoff, Regan E. Giesinger, Edward F. Bell & Patrick J. McNamara

Authors
  1. Adrianne Rahde Bischoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Regan E. Giesinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Edward F. Bell
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Patrick J. McNamara
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Patrick J. McNamara.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bischoff, A.R., Giesinger, R.E., Bell, E.F. et al. Precision medicine in neonatal hemodynamics: need for prioritization of mechanism of illness and defining population of interest. J Perinatol 40, 1446–1449 (2020). https://doi.org/10.1038/s41372-020-0741-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41372-020-0741-y

This article is cited by

Search

Advanced search

Quick links