Abstract
Objective
To determine whether antenatal depression is associated with oxidative stress and inflammation, and secondarily, whether the association between antenatal depression and spontaneous preterm birth (SPTB) is mediated by these biomarkers.
Study design
The primary outcome included urine oxidative stress biomarkers 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane and plasma inflammatory biomarkers measured at 10, 18, and 26 weeks and averaged within individual. Linear and logistic regression models were used, adjusting for age, race, parity, and pre-pregnancy body mass index.
Results
Among 462 women, 8-isoprostane was higher among depressed women (geometric mean: 299.96 pg/mL vs. 237.01 pg/mL; p = 0.001). In multivariable analyses, antenatal depression was significantly associated with an increase in average 8-isoprostane (β: 0.25; 95% CI: 0.05–0.44; p = 0.01). The association of antenatal depression with SPTB was partially mediated by 8-isoprostane. Antenatal depression was not associated with 8-OHdG or inflammatory biomarkers.
Conclusions
Antenatal depression was associated with higher oxidative stress across pregnancy, namely 8-isoprostane, and may impact SPTB via oxidative stress.
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Author contribution
KKV, TFM, and KKF conceptualized and designed this study. KKV, DEC, and KKF conducted all analyses. JDM, TFM, and DEC assisted with data interpretation. KKV and KKF wrote the manuscript.
Funding
This study was funded by the following grant from the National Institutes of Health (R01ES018872 NIH/NIEHS). Funding for Ferguson KK was provided by the Intramural Research Program of the National Institute of Environmental Health Sciences, National Institutes of Health.
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KKV has served on an advisory board for Sage Pharmaceuticals. The remaining authors declare that they have no conflict of interest.
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Venkatesh, K.K., Meeker, J.D., Cantonwine, D.E. et al. Association of antenatal depression with oxidative stress and impact on spontaneous preterm birth. J Perinatol 39, 554–562 (2019). https://doi.org/10.1038/s41372-019-0317-x
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DOI: https://doi.org/10.1038/s41372-019-0317-x
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