Abstract
Objective: To develop better therapy mode and reduce the rate of relapse of nephrotic syndrome in children with steroid sensitive nephrotic syndrome (SSNS).
Methods: Compared the effect of 2-month steroid treatment (standard course) according to International Study of Kidney Disease of Children (ISKDC) versus 6-month treatment (long course) on the clinical course of SSNS in a 2-year follow up in our centre. Long course of consisted from following: Prednisolone 60 mg/m2/day for 4 weeks, then 40 mg/m2/ alternate day for 4 weeks and slowly tapering off by 10 mg/m2/ alternate day in four months, total course of 6 months.
Medical records of patients seen from 2008-2010 were reviewed. A total of 56 patients were included in the study (standard course group=29, long course group=27). All patients were treated with steroid alone. We have excluded patients who were previously treated, those who suffered from steroid resistant nephritic syndrome.
Results: After following up for 2 years, the relapse rates of both groups were observed. Patients treated with long course steroid had significantly lower relapse rate (33% versus 75%, p= 0.026) and higher percentage of sustained remission (p=0.0046) than that of standard course. None of our patients had significant growth retardation or hypertension.
Conclusion: In conclusion, with the limitations and constraints in mind, the 6-month corticosteroid therapy is more likely to provide better rate of sustained remission when compared to the standard ISKDC regimen as the initial management of first episode SSNS.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sharipov, A., Khamzayev, K., Mamatkulov, B. et al. Different Corticosteroid Therapy Regimens for Nephrotic Syndrome in Children. Pediatr Res 70 (Suppl 5), 768 (2011). https://doi.org/10.1038/pr.2011.993
Issue Date:
DOI: https://doi.org/10.1038/pr.2011.993