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DNA: leukemia's secret weapon of bone mass destruction

Oncogene volume 32, pages 5199–5200 (2013)Cite this article

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Abstract

Interaction of tumour cells with their microenvironment impacts on all aspects of cancer, ranging from development through to treatment response. In this issue, Dvorak and colleagues1 reveal a novel tumour/microevironment relationship that may drive leukemia pathogenesis. Specifically, they find that leukemic cells secrete chromatin-complexed DNA that, in turn, triggers a variety of harmful effects, including cell death, in neighbouring stromal cells. Through this toxicity, DNA-mediated bone marrow destruction could promote disease progression by allowing leukemic cells to exit the bone marrow into the circulation.

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References

  1. Dvorakova M, Karafiat V, Pajer P, Kluzakova E, Jarkovska K, Pekova S et al. DNA released by leukemic cells contributes to the disruption of the bone marrow microenvironment. Oncogene (e-pub ahead of print 10 December 2012, doi: 10.1038/onc.2012.553).

    Article  PubMed  Google Scholar 

  2. Pattabiraman DR, Gonda TJ . Role and potential for therapeutic targeting of MYB in Leukemia. Leukemia (e-pub ahead of print 28 August 2012; doi: 10.1038/leu.2012.225).

    Article  PubMed  Google Scholar 

  3. Karafiat V, Dvorakova M, Pajer P, Kralova J, Horejsi Z, Cermak V et al. The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors. Blood 2001; 98: 3668–3676.

    Article  CAS  PubMed  Google Scholar 

  4. Dvorakova M, Kralova J, Karafiat V, Bartunek P, Dvorak M . An ex vivo model to study v-Myb-induced leukemogenicity. Blood Cells Mol Dis 2001; 27: 437–445.

    Article  CAS  PubMed  Google Scholar 

  5. Gahan PB, Stroun M . The virtosome-a novel cytosolic informative entity and intercellular messenger. Cell Biochem Funct 2010; 28: 529–538.

    Article  CAS  PubMed  Google Scholar 

  6. Nickel W . Pathways of unconventional protein secretion. Curr Opin Biotechnol 2010; 21: 621–626.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Cancer Sciences, University of Glasgow, Beatson Institute for Cancer Research, Glasgow, UK

    S Tait

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  1. S Tait
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Correspondence to S Tait.

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Tait, S. DNA: leukemia's secret weapon of bone mass destruction. Oncogene 32, 5199–5200 (2013). https://doi.org/10.1038/onc.2012.639

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  • DOI: https://doi.org/10.1038/onc.2012.639

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