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Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression

Oncogene volume 30, pages 445–456 (2011)Cite this article

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Abstract

Some subunits of the SWI/SNF complex function as tumor suppressors. However, underlying mechanisms are still incompletely defined. Here, we show that Srg3, a mouse homolog of BAF155 that function as a core subunit of this complex, suppresses tumorigenesis in vivo. DNA damage signals promoted Srg3 degradation by inducing p53. Deficiency of Srg3 promoted G1 cell-cycle arrest, but antagonized apoptotic response to DNA damage by robustly inducing p53 and p21 proteins. Srg3 heterozygous mice were prone to sarcoma formation, which was further enhanced by haploinsufficiency of p53. These tumors highly expressed p53 and p21 but lacked Srg3 expression. Our results establish a novel function of Srg3 in tumor suppression and provide insights into genetic pathways dictating tumor suppression by the SWI/SNF complex.

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Acknowledgements

This work was supported by grants from the National Research Foundation of Korea (NRF), funded by Ministry of Education, Science and Technology, in part through the Research Center for Functional Cellulomics and in part through the Priority Research Centers Program (2009-0094022). JA, MK, JK, HY and CL were supported by the BK21 program from MEST.

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  1. J Ahn and M Ko: These authors contributed equally to this work.

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  1. Department of Biological Sciences and Institute of Molecular Biology & Genetics, Research Center for Functional Cellulomics, Seoul National University, Seoul, Korea

    J Ahn, M Ko, C Lee, J Kim, H Yoon & R H Seong

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  1. J Ahn
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Correspondence to R H Seong.

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Ahn, J., Ko, M., Lee, C. et al. Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression. Oncogene 30, 445–456 (2011). https://doi.org/10.1038/onc.2010.424

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