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Enhanced interrogation: emerging strategies for cell signaling inhibition

Nature Structural & Molecular Biology volume 17, pages 646–649 (2010)Cite this article

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Abstract

Here we summarize recent and developing chemical approaches for modulating signaling pathways. In particular, we discuss targeting mutant signaling proteins, disrupting protein-protein interactions in cellular signaling networks, designing bivalent inhibitors of signaling proteins and identifying allosteric regulators of signaling enzymes. Over the past decade, great progress in the harvesting of chemical tools for basic research and clinical medicine has been made, but many challenges remain, and examples of exciting future targets are highlighted.

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Figure 1: Strategies for targeting signaling pathways.

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Acknowledgements

We are grateful for helpful suggestions from members of our laboratory and other collaborators and thank the US National Institutes of Health for financial support.

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Authors and Affiliations

  1. Isabel Martinez-Ferrando and Philip A. Cole are in the Department of Pharmacology and Molecular Sciences, Rong Huang, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.,

    Rong Huang, Isabel Martinez-Ferrando & Philip A Cole

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  1. Rong Huang
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  2. Isabel Martinez-Ferrando
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  3. Philip A Cole
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Correspondence to Philip A Cole.

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The authors declare no competing financial interests.

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Huang, R., Martinez-Ferrando, I. & Cole, P. Enhanced interrogation: emerging strategies for cell signaling inhibition. Nat Struct Mol Biol 17, 646–649 (2010). https://doi.org/10.1038/nsmb0610-646

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