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A parasite calcium switch and Achilles' heel revealed

Crystal structures of a calcium-dependent protein kinase from Toxoplasma gondii uncover a unique mechanism of activation and potential avenues for selective inhibition.

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Figure 1: Comparative schematic of activation of CDPKs (as elucidated by the study by Wernimont and colleagues7) and CaMKs.
Figure 2: ARKA approach followed by Ojo and colleagues6.

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Correspondence to Christian Doerig or Oliver Billker.

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Doerig, C., Billker, O. A parasite calcium switch and Achilles' heel revealed. Nat Struct Mol Biol 17, 541–543 (2010). https://doi.org/10.1038/nsmb0510-541

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