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Src defines a new pool of EGFR substrates

Nature Structural & Molecular Biology volume 22, pages 945–947 (2015)Cite this article

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The mechanisms guiding the substrate specificity of kinases are still poorly understood. Two recent reports provide further insights into how the epidermal growth factor receptor (EGFR) tyrosine kinase recognizes targets by identifying a new consensus motif that requires a Src-mediated priming phosphorylation.

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Figure 1: Structural basis for the binding of primed YY motifs to the EGFR kinase.
Figure 2: Distinct mechanisms of substrate recognition by the EGFR kinase modulate EGFR signaling output.

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References

  1. Dephoure, N., Gould, K.L., Gygi, S.P. & Kellogg, D.R. Mol. Biol. Cell 24, 535–542 (2013).

    Article  CAS  Google Scholar 

  2. Cohen, P. Trends Biochem. Sci. 25, 596–601 (2000).

    Article  CAS  Google Scholar 

  3. Park, E. et al. Nat. Struct. Mol. Biol. 22, 703–711 (2015).

    Article  CAS  Google Scholar 

  4. Begley, M.J. et al. Nat. Struct. Mol. Biol. 22, 983–990 (2015).

    Article  CAS  Google Scholar 

  5. Voldborg, B.R., Damstrup, L., Spang-Thomsen, M. & Poulsen, H.S. Ann. Oncol. 8, 1197–1206 (1997).

    Article  CAS  Google Scholar 

  6. Normanno, N. et al. Gene 366, 2–16 (2006).

    Article  CAS  Google Scholar 

  7. Tanoue, T., Adachi, M., Moriguchi, T. & Nishida, E. Nat. Cell Biol. 2, 110–116 (2000).

    Article  CAS  Google Scholar 

  8. Schulman, B.A., Lindstrom, D.L. & Harlow, E. Proc. Natl. Acad. Sci. USA 95, 10453–10458 (1998).

    Article  CAS  Google Scholar 

  9. Kõivomägi, M. et al. Nat. Struct. Mol. Biol. 20, 1415–1424 (2013).

    Article  Google Scholar 

  10. Levinson, N.M., Seeliger, M.A., Cole, P.A. & Kuriyan, J. Cell 134, 124–134 (2008).

    Article  CAS  Google Scholar 

  11. Fan, Y.X., Wong, L. & Johnson, G.R. Biochem. J. 392, 417–423 (2005).

    Article  CAS  Google Scholar 

  12. Chang, X. et al. PLoS One 8, e68966 (2013).

    Article  CAS  Google Scholar 

  13. Zhang, X. et al. Nature 450, 741–744 (2007).

    Article  CAS  Google Scholar 

  14. Jura, N. et al. Cell 137, 1293–1307 (2009).

    Article  Google Scholar 

  15. Biscardi, J.S. et al. J. Biol. Chem. 274, 8335–8343 (1999).

    Article  CAS  Google Scholar 

  16. Tice, D.A., Biscardi, J.S., Nickles, A.L. & Parsons, S.J. Proc. Natl. Acad. Sci. USA 96, 1415–1420 (1999).

    Article  CAS  Google Scholar 

  17. Kloth, M.T. et al. J. Biol. Chem. 278, 1671–1679 (2003).

    Article  CAS  Google Scholar 

  18. Wheeler, D.L. et al. Cancer Biol. Ther. 8, 696–703 (2009).

    Article  CAS  Google Scholar 

  19. Creixell, P. et al. Cell 163, 187–201 (2015).

    Article  CAS  Google Scholar 

  20. Kovacs, E. et al. Mol. Cell. Biol. 35, 3083–3102 (2015).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Nicole Michael and Natalia Jura are at the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.,

    Nicole Michael & Natalia Jura

  2. Natalia Jura is also at the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA.,

    Natalia Jura

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  1. Nicole Michael
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  2. Natalia Jura
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Correspondence to Natalia Jura.

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The authors declare no competing financial interests.

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Michael, N., Jura, N. Src defines a new pool of EGFR substrates. Nat Struct Mol Biol 22, 945–947 (2015). https://doi.org/10.1038/nsmb.3137

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