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It takes two to tangle: Prp24 and spliceosome assembly

Nature Structural & Molecular Biology volume 21, pages 503–504 (2014)Cite this article

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X-ray structural analysis of spliceosomal U6 small nuclear RNA bound to Prp24 reveals a complex interlocked RNA–protein assembly and suggests models for key steps in spliceosome assembly and recycling.

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Figure 1: Model of the U6 snRNP core complex.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Daniel A. Pomeranz Krummel is at the Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA.,

    Daniel A Pomeranz Krummel

  2. Andrew M. MacMillan is at the Department of Biochemistry, University of Alberta, Edmonton, Canada.,

    Andrew M MacMillan

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  1. Daniel A Pomeranz Krummel
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  2. Andrew M MacMillan
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Correspondence to Daniel A Pomeranz Krummel or Andrew M MacMillan.

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Pomeranz Krummel, D., MacMillan, A. It takes two to tangle: Prp24 and spliceosome assembly. Nat Struct Mol Biol 21, 503–504 (2014). https://doi.org/10.1038/nsmb.2838

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