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How YidC inserts and folds proteins across a membrane

Nature Structural & Molecular Biology volume 21, pages 435–436 (2014)Cite this article

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The crystal structure of the membrane insertase YidC reveals a hydrophilic groove in the cytoplasmic bilayer leaflet, suggesting a new mechanism of membrane-protein insertion.

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Figure 1: Stages of membrane insertion.

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Acknowledgements

This work was supported by US National Science Foundation grant MCB-1052033 to R.E.D. and Deutsche Forschungsgemeinschaft Ku749/6 to A.K.

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Authors and Affiliations

  1. Ross E. Dalbey is at the Department of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA.,

    Ross E Dalbey

  2. Andreas Kuhn is at the Institute of Microbiology and Molecular Biology, University of Hohenheim, Stuttgart, Germany.,

    Andreas Kuhn

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  1. Ross E Dalbey
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  2. Andreas Kuhn
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Correspondence to Ross E Dalbey.

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Dalbey, R., Kuhn, A. How YidC inserts and folds proteins across a membrane. Nat Struct Mol Biol 21, 435–436 (2014). https://doi.org/10.1038/nsmb.2823

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