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A 'pivotal' new rule for microRNA-mRNA interactions

Nature Structural & Molecular Biology volume 19, pages 265–266 (2012)Cite this article

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Finding biologically relevant targets is a prerequisite for understanding the function of any trans regulator of gene expression, but this can be particularly challenging with microRNAs (miRNAs). A study in this issue addresses the problem by identifying a novel mode of miRNA target recognition.

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Figure 1: Comparison between perfect seed match, nucleation bulge, short seed and non-nucleation bulge.

References

  1. Bartel, D.P. Cell 136, 215–233 (2009).

    Article  CAS  Google Scholar 

  2. Baek, D. et al. Nature 455, 64–71 (2008).

    Article  CAS  Google Scholar 

  3. Selbach, M. et al. Nature 455, 58–63 (2008).

    Article  CAS  Google Scholar 

  4. Chi, S.W., Hannon, G.J. & Darnell, R.B. Nat. Struct. Mol. Biol. 19, 321–327 (2012).

    Article  CAS  Google Scholar 

  5. Chi, S.W., Zang, J.B., Mele, A. & Darnell, R.B. Nature 460, 479–486 (2009).

    Article  CAS  Google Scholar 

  6. Zisoulis, D.G. et al. Nat. Struct. Mol. Biol. 17, 173–179 (2010).

    Article  CAS  Google Scholar 

  7. Vella, M.C., Choi, E.-Y., Lin, S.-Y., Reinert, K. & Slack, F.J. Genes Dev. 18, 132–137 (2004).

    Article  CAS  Google Scholar 

  8. Didiano, D. & Hobert, O. Nat. Struct. Mol. Biol. 13, 849–851 (2006).

    Article  CAS  Google Scholar 

  9. Ha, I., Wightman, B. & Ruvkun, G. Genes Dev. 10, 3041–3050 (1996).

    Article  CAS  Google Scholar 

  10. Tay, Y., Zhang, J., Thomson, A.M., Lim, B. & Rigoutsos, I. Nature 455, 1124–1128 (2008).

    Article  CAS  Google Scholar 

  11. Bhattacharyya, S.N., Habermacher, R., Martine, U., Closs, E.I. & Filipowicz, W. Cell 125, 1111–1124 (2006).

    Article  CAS  Google Scholar 

  12. van Kouwenhove, M., Kedde, M. & Agami, R. Nat. Rev. Cancer 11, 644–656 (2011).

    Article  CAS  Google Scholar 

  13. Vasudevan, S. & Steitz, J.A. Cell 128, 1105–1118 (2007).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Giovanni Stefani and Frank J. Slack are in the Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA.,

    Giovanni Stefani & Frank J Slack

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  1. Giovanni Stefani
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  2. Frank J Slack
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Correspondence to Frank J Slack.

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The authors declare no competing financial interests.

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Stefani, G., Slack, F. A 'pivotal' new rule for microRNA-mRNA interactions. Nat Struct Mol Biol 19, 265–266 (2012). https://doi.org/10.1038/nsmb.2256

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