Data from a retrospective cohort study indicate that regular intravesical instillations of gentamicin reduce the frequency of recurrent UTI. A total of 27 patients with ≥6 culture-confirmed treatment-refractory UTIs in the past year received nightly intravesical gentamicin infusions. Systemic absorption of gentamicin was generally limited, and treatment was discontinued in patients whose serum gentamicin levels routinely reached >1 mg/l. No adverse effects were reported with use of this approach, and the majority of patients (22) had a decrease in the incidence of UTI after commencing treatment.
References
Abrams, P. et al. The use of intravesical gentamicin to treat recurrent urinary tract infections in lower urinary tract dysfunction. Neurourol. Urodyn. http://dx.doi.org/10.1002/nau.23250 (2017)
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Sidaway, P. Intravesical gentamicin ameliorates recurrent UTI. Nat Rev Urol 14, 391 (2017). https://doi.org/10.1038/nrurol.2017.85
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DOI: https://doi.org/10.1038/nrurol.2017.85