2012 was a year of global controversy surrounding PSA screening—updated results were reported from the two largest trials and the US Preventative Services Task Force (USPSTF) released a Grade D recommendation against screening. Other data supported active surveillance for low-risk prostate cancer, whereas radical prostatectomy was shown to benefit those with intermediate-risk and high-risk disease.
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Hoag, N., Goldenberg, S. Paradigm shifts in prostate cancer diagnosis and treatment. Nat Rev Urol 10, 69–70 (2013). https://doi.org/10.1038/nrurol.2012.251
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DOI: https://doi.org/10.1038/nrurol.2012.251
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