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BPH in 2012

Novel agents in treatment of BPH

2012 in BPH has been characterized by studies investigating treatment options for BPH-associated lower urinary tract symptoms (LUTS). Onabotulinumtoxin A and saw palmetto have both been shown to be no more effective than placebo. However, in a positive move, tadalafil received FDA approval for LUTS treatment.

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References

  1. Avins, A. L. et al. Safety and Toxicity of Saw palmetto in the Complementary and Alternative Medicine for Urological Symptoms (CAMUS) Trial. J. Urol. http://dx.doi.org/10.1016/j.juro.2012.10.002.

  2. Barnes, J. Saw palmetto. Serenoa repens. Also known as Serenoa serrulata, Sabal serrulata and the dwarf palm. J. Prim. Health Care 1, 323 (2009).

    Article  Google Scholar 

  3. Bent, S. et al. Saw palmetto for benign prostatic hyperplasia. N. Engl. J. Med. 354, 557–566 (2006).

    Article  CAS  Google Scholar 

  4. Helfand, B. T. et al. Associations Between improvements in lower urinary tract symptoms and sleep disturbance over time in the CAMUS Trial. J. Urol. 188, 2288–2293 (2012).

    Article  Google Scholar 

  5. Marberger, M. et al. A randomized double-blind placebo-controlled phase 2 dose-ranging study of onabotulinumtoxinA in men with benign prostatic hyperplasia. Eur. Urol. http://dx.doi.org/10.1016/j.eururo.2012.10.005.

  6. Cohen, P. G. Intra-abdominal pressure, LUTS, and tadalafil. Re: Andersson K-E. et al. tadalafil for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: pathophysiology and mechanism(s) of action. Neurourol urodyn 2011;30, 292–301. Neurourol. Urodyn. 31, 706 (2012).

    Article  Google Scholar 

  7. Warde, N. Therapy: two birds, one stone: tadalafil is an effective treatment for men with both BPH-LUTS and ED. Nat. Rev. Urol. 8, 643 (2011).

    Article  Google Scholar 

  8. Gomelsky, A. & Dmochowski, R. R. Urodynamic effects of once-daily tadalafil in men with LUTS secondary to clinical BPH. Curr. Urol. Rep. 11, 254–260 (2010).

    Article  Google Scholar 

  9. Bechara, A. et al. Comparative efficacy assessment of tamsulosin vs. tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study. J. Sex. Med. 5, 2170–2178 (2008).

    Article  CAS  Google Scholar 

  10. Gacci, M. et al. A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with alpha-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia. Eur. Urol. 61, 994–1003 (2012).

    Article  CAS  Google Scholar 

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Correspondence to Bilal Chughtai.

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Chughtai, B., Te, A. Novel agents in treatment of BPH. Nat Rev Urol 10, 72–73 (2013). https://doi.org/10.1038/nrurol.2012.250

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