A meta-analysis of genome-wide association studies has revealed substantial overlap in the genetic loci linked to migraine and ischaemic stroke. Strong correlations were observed between the risk variants for migraine without aura and large-artery or cardioembolic strokes, and the authors speculate that platelet dysfunction could link these diseases. By contrast, migraine with aura had only a weak genetic relationship to ischaemic stroke.
References
Malik, R. et al. Shared genetic basis for migraine and ischemic stroke. Neurology 10.1212/WNL.0000000000001606
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Overlap between the genetic loci that confer risk of migraine and ischaemic stroke. Nat Rev Neurol 11, 309 (2015). https://doi.org/10.1038/nrneurol.2015.90
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DOI: https://doi.org/10.1038/nrneurol.2015.90