Migraine

Definition

Migraine refers to a group of primary headache disorders marked by recurrent unilateral headache episodes. Migraine headache is often described as moderate to severe pulsating pain. Migraine can occur with or without preceding symptoms (referred to as aura) and is often accompanied by nausea and increased sensitivity to light.

Latest Research and Reviews

  • Reviews |

    Medication-overuse headache (MOH) is a common disorder, but it remains under-recognized, and although several risk factors have been identified, the pathophysiology of the disorder is not completely understood. Here, Hans-Christoph Diener and colleagues review the epidemiology and pathophysiology of MOH, and suggest strategies for prevention and treatment.

    • Hans-Christoph Diener
    • , Dagny Holle
    • , Kasja Solbach
    •  & Charly Gaul
  • Research |

    Aarno Palotie and colleagues present results of a large genome-wide association study of migraine. They identified significant associations at 38 distinct loci and found enrichment for genes expressed in vascular and smooth muscle tissues.

    • Padhraig Gormley
    • , Verneri Anttila
    • , Bendik S Winsvold
    • , Priit Palta
    • , Tonu Esko
    • , Tune H Pers
    • , Kai-How Farh
    • , Ester Cuenca-Leon
    • , Mikko Muona
    • , Nicholas A Furlotte
    • , Tobias Kurth
    • , Andres Ingason
    • , George McMahon
    • , Lannie Ligthart
    • , Gisela M Terwindt
    • , Mikko Kallela
    • , Tobias M Freilinger
    • , Caroline Ran
    • , Scott G Gordon
    • , Anine H Stam
    • , Stacy Steinberg
    • , Guntram Borck
    • , Markku Koiranen
    • , Lydia Quaye
    • , Hieab H H Adams
    • , Terho Lehtimäki
    • , Antti-Pekka Sarin
    • , Juho Wedenoja
    • , David A Hinds
    • , Julie E Buring
    • , Markus Schürks
    • , Paul M Ridker
    • , Maria Gudlaug Hrafnsdottir
    • , Hreinn Stefansson
    • , Susan M Ring
    • , Jouke-Jan Hottenga
    • , Brenda W J H Penninx
    • , Markus Färkkilä
    • , Ville Artto
    • , Mari Kaunisto
    • , Salli Vepsäläinen
    • , Rainer Malik
    • , Andrew C Heath
    • , Pamela A F Madden
    • , Nicholas G Martin
    • , Grant W Montgomery
    • , Mitja I Kurki
    • , Mart Kals
    • , Reedik Mägi
    • , Kalle Pärn
    • , Eija Hämäläinen
    • , Hailiang Huang
    • , Andrea E Byrnes
    • , Lude Franke
    • , Jie Huang
    • , Evie Stergiakouli
    • , Phil H Lee
    • , Cynthia Sandor
    • , Caleb Webber
    • , Zameel Cader
    • , Bertram Muller-Myhsok
    • , Stefan Schreiber
    • , Thomas Meitinger
    • , Johan G Eriksson
    • , Veikko Salomaa
    • , Kauko Heikkilä
    • , Elizabeth Loehrer
    • , Andre G Uitterlinden
    • , Albert Hofman
    • , Cornelia M van Duijn
    • , Lynn Cherkas
    • , Linda M Pedersen
    • , Audun Stubhaug
    • , Christopher S Nielsen
    • , Minna Männikkö
    • , Evelin Mihailov
    • , Lili Milani
    • , Hartmut Göbel
    • , Ann-Louise Esserlind
    • , Anne Francke Christensen
    • , Thomas Folkmann Hansen
    • , Thomas Werge
    • , International Headache Genetics Consortium
    • , Verneri Anttila
    • , Ville Artto
    • , Andrea Carmine Belin
    • , Dorret I Boomsma
    • , Sigrid Børte
    • , Daniel I Chasman
    • , Lynn Cherkas
    • , Anne Francke Christensen
    • , Bru Cormand
    • , Ester Cuenca-Leon
    • , George Davey Smith
    • , Martin Dichgans
    • , Cornelia van Duijn
    • , Else Eising
    • , Tonu Esko
    • , Ann-Louise Esserlind
    • , Michel Ferrari
    • , Rune R Frants
    • , Tobias M Freilinger
    • , Nicholas A Furlotte
    • , Padhraig Gormley
    • , Lyn Griffiths
    • , Eija Hamalainen
    • , Thomas Folkmann Hansen
    • , Marjo Hiekkala
    • , M Arfan Ikram
    • , Andres Ingason
    • , Marjo-Riitta Järvelin
    • , Risto Kajanne
    • , Mikko Kallela
    • , Jaakko Kaprio
    • , Mari Kaunisto
    • , Christian Kubisch
    • , Mitja Kurki
    • , Tobias Kurth
    • , Lenore Launer
    • , Terho Lehtimaki
    • , Davor Lessel
    • , Lannie Ligthart
    • , Nadia Litterman
    • , Arn M J M van den Maagdenberg
    • , Alfons Macaya
    • , Rainer Malik
    • , Massimo Mangino
    • , George McMahon
    • , Bertram Muller-Myhsok
    • , Benjamin M Neale
    • , Carrie Northover
    • , Dale R Nyholt
    • , Jes Olesen
    • , Aarno Palotie
    • , Priit Palta
    • , Linda M Pedersen
    • , Nancy Pedersen
    • , Danielle Posthuma
    • , Patricia Pozo-Rosich
    • , Alice Pressman
    • , Lydia Quaye
    • , Olli Raitakari
    • , Markus Schürks
    • , Celia Sintas
    • , Kari Stefansson
    • , Hreinn Stefansson
    • , Stacy Steinberg
    • , David Strachan
    • , Gisela M Terwindt
    • , Marta Vila-Pueyo
    • , Maija Wessman
    • , Bendik S Winsvold
    • , William Wrenthal
    • , Huiying Zhao
    • , John-Anker Zwart
    • , Jaakko Kaprio
    • , Arpo J Aromaa
    • , Olli Raitakari
    • , M Arfan Ikram
    • , Tim Spector
    • , Marjo-Riitta Järvelin
    • , Andres Metspalu
    • , Christian Kubisch
    • , David P Strachan
    • , Michel D Ferrari
    • , Andrea C Belin
    • , Martin Dichgans
    • , Maija Wessman
    • , Arn M J M van den Maagdenberg
    • , John-Anker Zwart
    • , Dorret I Boomsma
    • , George Davey Smith
    • , Kari Stefansson
    • , Nicholas Eriksson
    • , Mark J Daly
    • , Benjamin M Neale
    • , Jes Olesen
    • , Daniel I Chasman
    • , Dale R Nyholt
    •  & Aarno Palotie
    Nature Genetics 48, 856–866

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