MRI can be used to identify biochemically distinct subtypes of glioblastoma, new work has shown. In 121 patients at a single institution, quantitative analysis of the shape, texture and edge sharpness of lesions identified three phenotypic clusters in which different molecular pathways were enriched. The clusters were validated in a second cohort of 144 patients from multiple institutions. The imaging approach provides a noninvasive technique for patient stratification and therapeutic optimization.
References
Itakura, H. et al. Magnetic resonance image features identify glioblastoma phenotypic subtypes with distinct molecular pathway activities. Sci. Transl. Med. 10.1126/scitranslmed.aaa7582
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MRI can help to stratify patients with glioblastoma. Nat Rev Neurol 11, 548 (2015). https://doi.org/10.1038/nrneurol.2015.166
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DOI: https://doi.org/10.1038/nrneurol.2015.166
