Whole-genome sequencing has revealed a chemokine gene cluster that influences age of onset in early-onset familial Alzheimer disease (AD). Lalli et al. sequenced the genomes of 72 individuals with this condition, and identified a haplotype that delayed disease onset by ∼10 years. Plasma levels of eotaxin-1, a chemokine encoded by a gene at the AD-associated locus, correlated with age of onset, and this molecule could be a therapeutic target.
References
Lalli, M. A. et al. Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease. Mol. Psychiatry 10.1038/mp.2015.131
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Chemokine modifies Alzheimer disease age of onset. Nat Rev Neurol 11, 547 (2015). https://doi.org/10.1038/nrneurol.2015.164
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DOI: https://doi.org/10.1038/nrneurol.2015.164
