A recent study of a large multi-ethnic cohort has shown that cumulative serum titres of antibodies against five common microbial pathogens are associated with an increased risk of cognitive impairment. Further studies are needed to better understand this risk and enable translation of the findings into effective preventative strategies.
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References
Schmidt, R. et al. Early inflammation and dementia: a 25-year follow-up of the HonoluluAsia Aging Study. Ann. Neurol. 52, 168–174 (2002).
van Exel, E. et al. Interaction of atherosclerosis and inflammation in elderly subjects with poor cognitive function. Neurology 61, 169–51701 (2003).
Katan, M. et al. Infectious burden and cognitive function: The Northern Manhattan Study. Neurology 80, 1209–1215 (2013).
Elkind, M.S. et al. Infectious burden and risk of stroke: The Northern Manhattan Study. Arch. Neurol. 67, 33–38 (2010).
Schneider, J.A., Boyle, P.A., Arvanitakis, Z., Bienias, J. L. & Bennett, D. A. Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons. Ann. Neurol. 62, 59–66 (2007).
Jaeger, L.B. et al. Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimers disease. Brain Behav. Immun. 23, 507–517 (2009).
Soscia, S.J. et al. The Alzheimers disease-associated amyloid β-protein is an antimicrobial peptide. PLoS ONE 5, e9505 (2010).
Holmes, C. et al. Systemic inflammation and disease progression in Alzheimer disease. Neurology 73, 768–774 (2009).
Ball, M.J., Lukiw, W. J., Kammerman, E. M. & Hill, J. M. Intracerebral propagation of Alzheimer's disease: strengthening evidence of a herpes simplex virus etiology. Alzheimers Dement. 9, 169–175 (2013).
Swardfager, W. et al. Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease. Brain Behav. Immun. 25, 1264–1271 (2011).
Acknowledgements
W. Swardfager acknowledges support from the Neuropsychopharmacology Research Group, Sunnybrook Research Institute, the Toronto Rehabilitation Institute and the Heart and Stroke Foundation Centre for Stroke Recovery, Toronto, ON, Canada. S. E. Black acknowledges support from the Department of Medicine, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, and the Brill Chair in Neurology, Department of Medicine, University of Toronto.
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Swardfager, W., Black, S. A link between microbial infection and cognition?. Nat Rev Neurol 9, 301–302 (2013). https://doi.org/10.1038/nrneurol.2013.93
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DOI: https://doi.org/10.1038/nrneurol.2013.93
