Consistent with previous findings, two recent studies of temporal lobectomy from Kerala, India demonstrate that early seizure recurrence bodes poorly for long-term seizure control, and that relapse following drug discontinuation affects one-third of patients. Key questions in the field now concern advanced preoperative and intraoperative techniques for improving surgical outcomes.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Epilepsy surgery for refractory seizures: a systematic review and meta-analysis in different complications
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Open Access 12 March 2020
-
Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography
Brain Structure and Function Open Access 30 October 2013
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ramesha, K. N., Mooney, T., Sarma, P. S. & Radhakrishnan, K. Long-term seizure outcome and its predictors in patients with recurrent seizures during the first year after temporal lobe resective epilepsy surgery. Epilepsia doi:10.1111/j.1528–11672010.02891.x.
Rathore, C., Panda, S., Sarma, P. S. & Radhakrishnan, K. How safe is it to withdraw antiepileptic drugs following successful surgery for mesial temporal lobe epilepsy? Epilepsia 52, 627–635 (2011).
Sperling, M. R., O'Connor, M. J., Saykin, A. J. & Plummer, C. Temporal lobectomy for refractory epilepsy. JAMA 276, 470–475 (1996).
Spencer, S. S. et al. Predicting long-term seizure outcome after resective epilepsy surgery: the multicenter study. Neurology 65, 912–918 (2005).
McIntosh, A., Kalnins, R., Mitchell, L. & Berkovic, S. Early seizures after temporal lobectomy predict subsequent seizure recurrence. Ann. Neurol. 57, 283–288 (2005).
Jeha, L. E. et al. Predictors of outcome after temporal lobectomy for the treatment of intractable epilepsy. Neurology 66, 1938–1940 (2006).
Berg, A. T. et al. Reduction of AEDs in postsurgical patients who attain remission. Epilepsia 47, 64–71 (2006).
McIntosh, A. M., Wilson, S. J. & Berkovic, S. F. Seizure outcome after temporal lobectomy: current research practice and findings. Epilepsia 42, 1288–1307 (2001).
Bell, M. L. et al. Epilepsy surgery outcomes in temporal lobe epilepsy with a normal MRI. Epilepsia 50, 2053–2060 (2009).
Wu, J. Y. et al. Removing interictal fast ripples on electrocorticography linked with seizure freedom in children. Neurology 75, 1686–1694 (2010).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Berg, A. Efficacy of epilepsy surgery: what are the questions today?. Nat Rev Neurol 7, 311–312 (2011). https://doi.org/10.1038/nrneurol.2011.73
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2011.73
This article is cited by
-
Epilepsy surgery for refractory seizures: a systematic review and meta-analysis in different complications
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery (2020)
-
Low-frequency stimulation of the external globus palladium produces anti-epileptogenic and anti-ictogenic actions in rats
Acta Pharmacologica Sinica (2015)
-
Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography
Brain Structure and Function (2015)
