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  • Year in Review
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Multiple sclerosis in 2011

Advances in therapy, imaging and risk factors in MS

Nature Reviews Neurology volume 8, pages 66–68 (2012)Cite this article

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Multiple sclerosis research in 2011 produced a combination of new therapeutic developments and innovative findings. Teriflunomide showed beneficial effects in a phase III trial, quantification methods for MRI lesions that should improve monitoring of disease progression were devised, and a link between high cholesterol and low vitamin D emerged.

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References

  1. O'Connor, P. et al. Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N. Engl. J. Med. 365, 1293–1303 (2011).

    Article  CAS  Google Scholar 

  2. Sormani, M. P. et al. Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies. PLoS ONE 6, e26712 (2011).

    Article  CAS  Google Scholar 

  3. Weinstock-Guttman, B. et al. Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis. J. Neuroinflammation 8, 127 (2011).

    Article  CAS  Google Scholar 

  4. Weinstock-Guttman, B., Zivadinov, R. & Ramanathan, M. Inter-dependence of vitamin D levels with serum lipid profiles in multiple sclerosis. J. Neurol. Sci. 311, 86–91 (2011).

    Article  CAS  Google Scholar 

  5. Kappos, L. et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N. Engl. J. Med. 362, 387–401 (2010).

    Article  CAS  Google Scholar 

  6. Calabrese, M., Filippi, M. & Gallo, P. Cortical lesions in multiple sclerosis. Nat. Rev. Neurol. 6, 438–444 (2010).

    Article  Google Scholar 

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Acknowledgements

The authors would like to thank the Department of Defense, the Jog for The Jake Foundation, National Multiple Sclerosis Society, National Science Foundation and NIH for providing financial support for their research activities.

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Authors and Affiliations

  1. Jacobs Neurological Institute, Buffalo General Hospital, University at Buffalo, State University of New York, Building E, 2nd Floor, 100 High Street, Buffalo, 14203, NY, USA

    Bianca Weinstock–Guttman

  2. Department of Pharmaceutical Sciences and Neurology, State University of New York, 427 Cooke Hall, Buffalo, 14260, NY, USA

    Murali Ramanathan

Authors
  1. Bianca Weinstock–Guttman
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  2. Murali Ramanathan
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Correspondence to Bianca Weinstock–Guttman.

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Competing interests

B. Weinstock–Guttman has received honoraria for speaking and been on advisory boards of Teva Neuroscience, Biogen Idec, EMD Serono, Novartis and Pfizer. She has received financial support for research activities from EMD Serono, Acorda, Biogen Idec, Teva Neuroscience, Novartis, and Cyberonics. These are unrelated to the research presented in this report. M. Ramanathan has received research funding from EMD Serono, Pfizer and Novartis. He has received compensation as a consultant for Netezza, Biogen Idec and Allergan and from the American Association of Pharmaceutical Scientists for serving as an Associate Editor. These are unrelated to the research presented in this report.

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Weinstock–Guttman, B., Ramanathan, M. Advances in therapy, imaging and risk factors in MS. Nat Rev Neurol 8, 66–68 (2012). https://doi.org/10.1038/nrneurol.2011.213

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