The most appropriate treatment for absence seizures and the teratogenic effects of valproate were clarified in 2010. Advances were also made in the use of both functional MRI to predict the adverse effects of neurosurgical resection and electrical stimulation to control epilepsy in patients who are not suitable for resection.
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References
Kwan, P. & Brodie, M. J. Early identification of refractory epilepsy. N. Engl. J. Med. 342, 314–319 (2000).
Wang, W. Z. et al. Efficacy assessment of phenobarbital in epilepsy: a large community-based intervention trial in rural China. Lancet Neurol. 5, 46–52 (2006).
Glauser, T. A. et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N. Engl. J. Med. 362, 790–799 (2010).
Morrow, J. et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J. Neurol. Neurosurg. Psychiatry 77, 193–198 (2006).
Meador, K. J. et al. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. N. Engl. J. Med. 360, 1597–1605 (2009).
Jentink, J. et al. Valproic acid monotherapy in pregnancy and major congenital malformations. N. Engl. J. Med. 362, 2185–2193 (2010).
Duncan, J. S. Imaging in the surgical treatment of epilepsy. Nat. Rev. Neurol. 6, 537–550 (2010).
Bonelli, S. B. et al. Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection. Brain 133, 1186–1199 (2010).
Jacobs, J. et al. High-frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery. Ann. Neurol. 67, 209–220 (2010).
Fisher, R. et al. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia 51, 899–908 (2010).
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J. S. Duncan has received research and educational grant support—via University College London (UCL) and The Epilepsy Society—from Cyberonics, Eisai, GE Healthcare, GlaxoSmithKline, Janssen-Cilag, Medtronic and UCB Pharma. He has also acted as a consultant for Cyberonics, via UCL Consultants.
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Duncan, J. Refinement of optimal medical and surgical treatments. Nat Rev Neurol 7, 72–74 (2011). https://doi.org/10.1038/nrneurol.2010.213
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DOI: https://doi.org/10.1038/nrneurol.2010.213