A new study has compared the utility of optical coherence tomography and visual evoked potentials in the diagnosis of optic neuritis—an inflammatory condition that is frequently the presenting symptom of multiple sclerosis. The results indicate that the two techniques can provide complementary information for the diagnosis of this condition.
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References
Balcer, L. J. Clinical practice. Optic neuritis. N. Engl. J. Med. 354, 1273–1280 (2006).
Frohman, E. M. et al. Optical coherence tomography: a window into the mechanisms of multiple sclerosis. Nat. Clin. Pract. Neurol. 4, 664–675 (2008).
Naismith, R. T. et al. Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis. Neurology 73, 46–52 (2009).
Fisher, J. B. et al. Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophthalmology 113, 324–332 (2006).
Costello, F. et al. Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann. Neurol. 59, 963–969 (2006).
Gordon-Lipkin, E. et al. Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology 69, 1603–1609 (2007).
Pulicken, M. et al. Optical coherence tomography and disease subtype in multiple sclerosis. Neurology 69, 2085–2092 (2007).
Grazioli, E. et al. Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis. J. Neurol. Sci. 268, 12–17 (2008).
Henderson, A. P. et al. An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography. Brain 131, 277–287 (2008).
Selhorst, J. B. & Saul, R. F. Uhthoff and his symptom. J. Neuroophthalmol. 15, 63–69 (1995).
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Frohman, E., Balcer, L. & Calabresi, P. Can retinal imaging accurately detect optic neuritis?. Nat Rev Neurol 6, 125–126 (2010). https://doi.org/10.1038/nrneurol.2010.13
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DOI: https://doi.org/10.1038/nrneurol.2010.13
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