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Prion disease

Brain MRI studies in prion disease

Prion diseases are fatal and untreatable neurodegenerative brain diseases that can mimic other brain illnesses. Therapies for these conditions are most likely to work in the early stages of the disease, but no simple, early diagnostic tests are currently available. New findings, however, indicate that brain MRI could aid diagnosis.

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References

  1. Zerr, I. et al. Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt–Jakob disease. Neurology 55, 811–815 (2000).

    Article  CAS  Google Scholar 

  2. Collie, D. A. et al. Diagnosing variant Creutzfeldt–Jakob diease with the pulvinar sign: MR imaging findings in 86 neuropathologically confirmed cases. AJNR Am. J. Neuroradiol. 24, 1560–1569 (2003).

    PubMed  Google Scholar 

  3. Lodi, R. et al. Magnetic resonance diagnostic markers in clinically sporadic prion disease: a combined brain magnetic resonance imaging and spectroscopy study. Brain 132, 2669–2679 (2009).

    Article  Google Scholar 

  4. Zerr, I. et al. Updated clinical diagnostic criteria for sporadic Creutzfeldt–Jakob disease. Brain 132, 2659–2668 (2009).

    Article  CAS  Google Scholar 

  5. Parchi, P. et al. Classification of sporadic CJD based on molecular and phenotypic analysis of 300 subjects. Ann. Neurol. 46, 224–233 (1999).

    Article  CAS  Google Scholar 

  6. Meissner, B. et al. MRI lesion profiles in sporadic Creutzfeldt–Jakob disease. Neurology 72, 1994–2001 (2009).

    Article  CAS  Google Scholar 

  7. Pocchiari, M. et al. Predictors of survival in sporadic Creutzfeldt–Jakob disease and other human transmissible spongiform encephalopathies. Brain 127, 2348–2359 (2004).

    Article  CAS  Google Scholar 

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Knight, R. Brain MRI studies in prion disease. Nat Rev Neurol 6, 10–11 (2010). https://doi.org/10.1038/nrneurol.2009.212

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