A hybrid cytokine created by linking IL-2 and IL-33 (IL233) might protect against acute kidney injury (AKI). In mice, IL233 increased the numbers of regulatory T (Treg) cells in the blood, spleen and kidneys and prevented renal ischaemia–reperfusion injury (IRI) more efficiently than did IL-2 and IL-33. Treatment with IL233 also increased the proportion of innate lymphoid cells that expressed the IL-33 receptor (ILC2 cells) in the blood and kidneys. Adoptive transfer of IL233-treated Treg cells or ILC2 cells protected mice against IRI, suggesting that IL233 enhances the protective effects of these cells in the setting of AKI.
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19 June 2017
In the original html and PDF versions of this article, IL-2 was incorrectly written as IL-22 in two places and IL-33 was incorrectly written as IL-23 in the first sentence. These errors have now been corrected.
References
Stremska, M. E. et al. IL233, a novel IL-2 and IL-33 hybrid cytokine ameliorates renal injury. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2016121272 (2017)
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Carney, E. Targeting Treg cells to protect the kidney. Nat Rev Nephrol 13, 444 (2017). https://doi.org/10.1038/nrneph.2017.90
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DOI: https://doi.org/10.1038/nrneph.2017.90
