Chronic acidosis has previously been shown to induce an increase in acid-secreting α-intercalated cells and a decrease in HCO3-secreting β-intercalated cells in the cortical collecting duct (CCD), resulting in a net increase in CCD acid secretion. Now, Schwartz et al. report that the principal cells of the CCD are the sensors of acid levels. Using isolated CCDs, transgenic mice and cultured principal cells, they showed that these cells respond to acid by upregulating stromal cell-derived factor 1, which induces the change in intercalated cell subtype distribution that occurs in response to chronic acidosis.
References
Schwartz, G. J. et al. SDF1 induction by acidosis from principal cells regulates intercalated cell subtype distribution. J. Clin. Invest. 10.1172/JCI80225
Rights and permissions
About this article
Cite this article
Carney, E. Acid sensing in the collecting duct. Nat Rev Nephrol 12, 2 (2016). https://doi.org/10.1038/nrneph.2015.187
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2015.187