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Acute kidney injury

Can remote ischaemic preconditioning prevent AKI?

Nature Reviews Nephrology volume 11, pages 512–513 (2015)Cite this article

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A randomized multicentre controlled study of 240 cardiac surgery patients at high risk of acute kidney injury (AKI) has demonstrated that remote ischaemic preconditioning can reduce the rate of AKI and requirement for renal replacement therapy. These findings suggest this procedure could be a promising therapeutic option for this high-risk patient group.

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Acknowledgements

The research in the laboratory of J.V.B. is supported by grants DK39773 and DK72381 awarded by the NIH.

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Authors and Affiliations

  1. Renal Division and Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 4 Blackfan Circle, Boston, 02115, MA, USA

    Anna Zuk & Joseph V. Bonventre

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  1. Anna Zuk
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  2. Joseph V. Bonventre
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Corresponding author

Correspondence to Joseph V. Bonventre.

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Competing interests

J.V.B. consults on AKI for Astellas Pharma, AbbVie, and Takeda and consults and holds equity in MediBeacon, Sentien Biotechnologies, Inc., and Thrasos Therapeutics. J.V.B. is a co-inventor on KIM-1 patents assigned to Partners HealthCare and licensed to Johnson & Johnson, Sekisui Diagnostics LLC, Novartis, Biogen IDEC, and Astute Medical. He has received grant support from Novo Nordisk and Roche. A.Z. declares no competing interests.

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Zuk, A., Bonventre, J. Can remote ischaemic preconditioning prevent AKI?. Nat Rev Nephrol 11, 512–513 (2015). https://doi.org/10.1038/nrneph.2015.119

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