RGS5 has a key role in regulating blood pressure during pregnancy through interactions with Ang II and PPAR signalling, according to new research. Holobotovskyy et al. found that expression of RGS5 was reduced in the myometrial vessels of women with gestational hypertension or pre-eclampsia. Pregnant Rgs5-deficient mice had enhanced vascular sensitivity to Ang II, resulting in gestational hypertension, whereas administration of PPAR agonists to pregnant heterozygous mice normalized vascular function and blood pressure through effects on Rgs5.
References
Holobotovskyy, V. et al. Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia. Sci. Transl. Med. 10.1126/scitranslmed.aaa5038
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RGS5 as a mediator of gestational hypertension. Nat Rev Nephrol 11, 444 (2015). https://doi.org/10.1038/nrneph.2015.101
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DOI: https://doi.org/10.1038/nrneph.2015.101
