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Familial aggregation of ESRD in Europeans—is it in the genes?

Nature Reviews Nephrology volume 10, pages 677–678 (2014)Cite this article

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A new population-based study of a Norwegian registry containing data on more than 5 million individuals has confirmed the existence of powerful familial clustering of complex aetiologies of end-stage renal disease. Novel strategies for identifying additional nephropathy risk genes will benefit from such large familial registries.

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References

  1. Skrunes, R., Svarstad, E., Reisaeter, A. V. & Vikse, B. E. Familial Clustering of ESRD in the Norwegian Population. Clin. J. Am. Soc. Nephrol. http://dx.doi.org/10.2215/CJN.01680214.

  2. Seaquist, E. R., Goetz, F. C., Rich, S. & Barbosa, J. Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N. Engl. J. Med. 320, 1161–1165 (1989).

    Article  CAS  PubMed  Google Scholar 

  3. Maeda, S. et al. A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase β gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet. 6, e1000842 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Pezzolesi, M. G. et al. Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy. Diabetes 58, 2698–2702 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Genovese, G. et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329, 841–845 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Freedman, B. I. et al. The Apolipoprotein L1 (APOL1) Gene and Nondiabetic Nephropathy in African Americans. J. Am. Soc. Nephrol. 21, 1422–1426 (2010).

    Article  CAS  PubMed  Google Scholar 

  7. Freedman, B. I. & Skorecki, K. Gene-Gene and Gene-Environment Interactions in Apolipoprotein L1 Gene-Associated Nephropathy. Clin. J. Am. Soc. Nephrol. http://dx.doi.org/10.2215/CJN.01330214.

  8. Freedman, B. I., Spray, B. J., Tuttle, A. B. & Buckalew, V. M. Jr., The familial risk of end-stage renal disease in African Americans. Am. J. Kidney Dis. 21, 387–393 (1993).

    Article  CAS  PubMed  Google Scholar 

  9. Santin, S. et al. Clinical utility of genetic testing in children and adults with steroid-resistant nephrotic syndrome. Clin. J. Am. Soc. Nephrol. 6, 1139–1148 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Bleyer, A. J., Hart, P. S. & Kmoch, S. Hereditary interstitial kidney disease. Semin. Nephrol. 30, 366–373 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, 27157, NC, USA

    Barry I. Freedman & Todd W. Robinson

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  1. Barry I. Freedman
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  2. Todd W. Robinson
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Correspondence to Barry I. Freedman.

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Freedman, B., Robinson, T. Familial aggregation of ESRD in Europeans—is it in the genes?. Nat Rev Nephrol 10, 677–678 (2014). https://doi.org/10.1038/nrneph.2014.181

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