Haemodialysis improves some aspects of cardiovascular health, but whether home (5–6 times per week) or in-centre (3 times per week) haemodialysis is more effective in this regard is unknown. The risk of hospitalization and mortality due to all causes were similar in patients receiving home (n = 3,480) or in-centre (n = 17,400) haemodialysis. The home haemodialysis group had significantly lower risk of hospitalization with cardiovascular disease, but significantly greater risk with infection, which suggests better prevention of infection is required in patients on home haemodialysis.