Plasma copeptin is a marker of vasopressin and, in autosomal dominant polycystic kidney disease (ADPKD), might also indicate the extent of kidney damage. Patients with ADPKD (n = 122) had significantly higher mean plasma copetin levels than healthy kidney donors (n = 134), before and after donation (P <0.001). In these patients, but not in kidney donors, copeptin was significantly associated with glomerular filtration rate (P <0.001), implying that plasma copeptin is an ADPKD-specific indicator of renal function.
References
Zittema, D. et al. Kidney function and plasma copeptin levels in healthy kidney donors and autosomal dominant polycystic kidney disease patients. Clin. J. Am. Soc. Nephrol. 10.2215/CJN.08690813
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Plasma copeptin levels reflect ADPKD-induced GFR decline. Nat Rev Nephrol 10, 482 (2014). https://doi.org/10.1038/nrneph.2014.129
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DOI: https://doi.org/10.1038/nrneph.2014.129
