A new study reports that simultaneous pancreas–kidney transplantation effectively reverses the microvascular structural abnormalities of patients with diabetic nephropathy within 1 year of transplantation. Using sidestream dark field imaging, Khairoun et al. found that capillary tortuosity was increased in transplant naive patients with type 1 diabetic nephropathy but reversed by simultaneous pancreas–kidney transplantation. By contrast, capillary tortuosity in kidney transplant recipients was not different to that of untransplanted patients. The ratio of circulating angiopoietin-2 to angiopoietin-1 was also decreased after simultaneous organ transplantation.
ORIGINAL RESEARCH PAPER
Khairoun, M. et al. Microvascular damage in type 1 diabetic patients is reversed in the first year after simultaneous pancreas–kidney transplantation. Am. J. Transplant. DOI:10.1111/ajt.12182
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Reversal of microvascular damage in patients with type 1 diabetes after pancreas–kidney transplantation. Nat Rev Nephrol 9, 186 (2013). https://doi.org/10.1038/nrneph.2013.26
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DOI: https://doi.org/10.1038/nrneph.2013.26