Inhibition of the antiangiogenic factor soluble Fms-like tyrosine kinase-1 (sFlt-1) might improve renal transplantation outcomes, say researchers. Chapal et al. found that during the first week after transplantation, sFlt-1 levels increased 2–3-fold in 136 renal transplant recipients. The increase in sFlt-1 levels was greater in recipients of deceased-donor grafts than in recipients of living-donor grafts, and peak plasma sFlt-1 levels ≥250 pg/ml were associated with a 2.5-fold increase in the risk of delayed graft function, and with early loss of peritubular capillaries.
ORIGINAL RESEARCH PAPER
Chapal, M. et al. Increased soluble Flt-1 correlates with delayed graft function and early loss of peritubular capillaries in the kidney graft. Transplantation doi:10.1097/TP.0b013e31829f4772
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sFlt1—an independent risk factor for delayed graft function?. Nat Rev Nephrol 9, 554 (2013). https://doi.org/10.1038/nrneph.2013.157
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DOI: https://doi.org/10.1038/nrneph.2013.157