SIRT1 signalling is involved in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) and may represent a new therapeutic target for this disease, say researchers. Zhou et al. found that Sirt1 levels were upregulated in a mouse model of ADPKD. Deletion or inhibition of Sirt1 delayed renal cyst formation. The researchers propose that Sirt1 regulates epithelial cell proliferation and death via pathways involving Rb and p53.
ORIGINAL RESEARCH PAPER
Zhou, X. et al. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J. Clin. Invest. doi:10.1172/JCI64401
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Role of SIRT1 in ADPKD pathophysiology. Nat Rev Nephrol 9, 433 (2013). https://doi.org/10.1038/nrneph.2013.119
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DOI: https://doi.org/10.1038/nrneph.2013.119