Oral fluoroquinolone use is associated with an increased risk of acute kidney injury (AKI) in men, say researchers. Bird et al. examined the association in a case–control study using data from men aged 40–85 years from a US health plan claims database. Current use of oral fluoroquinolones was associated with a 2.18-fold increase in the relative risk of AKI compared with no use, but recent or past use of these drugs was not associated with AKI. Use of fluoroquinolones together with renin–angiotensin–aldosterone inhibitors was associated with an even greater increase in risk of AKI.