A humoral response to mismatched HLA antigens is an important contributor to chronic allograft injury (CAI). However, a panel of non-HLA antibodies that correlate with CAI have now been identified and validated in renal transplant recipients. The researchers say that measuring pretransplant serum levels of antibodies to CXCL9, CXCL11, IFN-γ and glial-derived neurotrophic factor could be used to stratify risk of developing CAI.
ORIGINAL RESEARCH PAPER
Sigdel, T. K. et al. Non-HLA antibodies to immunogenic epitopes predict the evolution of chronic renal allograft injury. J. Am. Soc. Nephrol. doi:10.1681/ASN.2011060596
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Non-HLA antibodies predict development of CAI. Nat Rev Nephrol 8, 193 (2012). https://doi.org/10.1038/nrneph.2012.28
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DOI: https://doi.org/10.1038/nrneph.2012.28