Crosstalk between equilibrative nucleoside transporter 1 (ENT1) and adenosine receptors has a role in regulating postischemic blood flow during acute kidney injury (AKI). Inhibition of ENTs in mice exposed to ischemic AKI led to an increase in adenosine levels and kidney protection. The attenuation of adenosine transport through Ent1 involves the adenosine receptor Adora2b, which contributes to the prevention of the renal no-reflow phenomenon.