Ongoing research continues to show only moderate accuracy of all methods of measuring proteinuria in pregnant women with hypertension. We need to change traditional thinking so that emphasis on the detection or quantitation of proteinuria is not greater than emphasis on other clinical or laboratory features in the diagnosis or management of pre-eclampsia.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chesley, L. C. Hypertensive Disorders in Pregnancy 1st edn 17–34 (Appleton-Century-Crofts, New York, 1978).
Lindheimer, M. D. & Kanter, D. Interpreting abnormal proteinuria in pregnancy: the need for a more pathophysiological approach. Obstet. Gynecol. 115, 365–375 (2010).
Benton, S. J. et al. Angiogenic factors as diagnostic tests for preeclampsia: a performance comparison between two commercial immunoassays. Am. J. Obstet. Gynecol. 205, 469.e1–469.e8 (2011).
Saudan, P. J., Brown, M. A., Farrell, T. & Shaw, L. Improved methods of assessing proteinuria in hypertensive pregnancy. Br. J. Obstet. Gynaecol. 104, 1159–1164 (1997).
National Institute for Health and Clinical Excellence. Hypertension in pregnancy: the management of hypertensive disorders during pregnancy [online], (2010).
Morris, R. K., Riley, R. D., Doug, M., Deeks, J. J. & Kilby, M. D. Diagnostic accuracy of spot urinary protein and albumin to creatinine ratios for detection of significant proteinuria or adverse pregnancy outcome in patients with suspected pre-eclampsia: systematic review and meta-analysis. BMJ 345, e4342 (2012).
Côté, A. M. et al. Diagnostic accuracy of urinary spot protein:creatinine ratio for proteinuria in hypertensive pregnant women: systematic review. BMJ 336, 1003–1006 (2008).
Chan, P., Brown, M., Simpson, J. M. & Davis, G. Proteinuria in pre-eclampsia: how much matters? BJOG 112, 280–285 (2005).
Homer, C. S., Brown, M. A., Mangos, G. & Davis, G. K. Non-proteinuric pre-eclampsia: a novel risk indicator in women with gestational hypertension. J. Hypertens. 26, 295–302 (2008).
Berks, D., Steegers, E. A., Molas, M. & Visser, W. Resolution of hypertension and proteinuria after preeclampsia. Obstet. Gynecol. 114, 1307–1314 (2009).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Brown, M. Proteinuria in pre-eclampsia—does it matter any more?. Nat Rev Nephrol 8, 563–565 (2012). https://doi.org/10.1038/nrneph.2012.190
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2012.190
This article is cited by
-
First Trimester Prediction of Preeclampsia
Current Hypertension Reports (2015)