The timing of mesenchymal stromal cell (MSC) infusion has an effect on their immunomodulatory and inflammatory properties, say researchers. Casiraghi and colleagues demonstrated, using a sensitized mouse model of kidney transplantation, that infusion of syngeneic MSCs before transplantation resulted in the expansion of donor-specific T-regulatory cells into lymphoid organs, prolonged allograft survival and promoted the development of tolerance. By contrast, post-transplantation infusion of MSCs led to premature graft dysfunction.
ORIGINAL RESEARCH PAPER
Casiraghi, F. et al. Localization of mesenchymal stromal cells dictates their immune or proinflammatory effects in kidney transplantation. Am. J. Transplant. doi:10.1111/j.1600-6143.2012.04115.x
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Timing of MSC infusion affects immune tolerance. Nat Rev Nephrol 8, 434 (2012). https://doi.org/10.1038/nrneph.2012.127
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DOI: https://doi.org/10.1038/nrneph.2012.127