Results of a clinical trial reported in the New England Journal of Medicine suggest that the use of recombinant tissue plasminogen activator as a lock solution improves catheter patency and reduces the risk of catheter-related infections. These effects have important clinical and economic ramifications. So why is tissue plasminogen activator not more widely used?
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Besarab, A., Moore, C. Two for the price of one: is rt-PA ready for prime time?. Nat Rev Nephrol 7, 310–311 (2011). https://doi.org/10.1038/nrneph.2011.54
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DOI: https://doi.org/10.1038/nrneph.2011.54
