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Chronic kidney disease

Endogenous filtration markers—is it time to move beyond eGFR?

Nature Reviews Nephrology volume 8, pages 10–12 (2012)Cite this article

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For predicting complications related to chronic kidney disease, endogenous filtration markers such as cystatin C and creatinine perform as well, if not better, than measured glomerular filtration rate (GFR). Measured GFR by clearance of an inert exogenous marker may still be the gold standard measure of GFR, but determining GFR may not answer the right clinical question.

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Figure 1: Mean changes in levels (and 95% CI) of metabolic complications among patients with CKD.

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Authors and Affiliations

  1. Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, 200 1st Street SW, Rochester, 55905, MN, USA

    Andrew D. Rule & Hisham Elsherbiny

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  1. Andrew D. Rule
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  2. Hisham Elsherbiny
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Correspondence to Andrew D. Rule.

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The authors declare no competing financial interests.

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Rule, A., Elsherbiny, H. Endogenous filtration markers—is it time to move beyond eGFR?. Nat Rev Nephrol 8, 10–12 (2012). https://doi.org/10.1038/nrneph.2011.193

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