The impact of brain region and ageing on microglia is unknown. Grabert et al. analysed transcriptomes of microglia from different brain regions (including the hippocampus, cortex and cerebellum) in 4-, 12- and 22-month-old mice using various clustering techniques. They found that differences in the expression of bioenergetics- and immune-related genes best differentiated microglia from different regions at 4 months, and that changes in expression with age were also region-specific.
References
Grabert, K. et al. Microglial brain region-dependent diversity and selective regional sensitivities to aging. Nat. Neurosci. http://dx.doi.org/10.1038/nn.4222 (2016)
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Bray, N. Old and young, far and wide. Nat Rev Neurosci 17, 138 (2016). https://doi.org/10.1038/nrn.2016.16
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DOI: https://doi.org/10.1038/nrn.2016.16