Abstract
The discovery of the signal-recognition particle (SRP) and its receptor represented a huge step forwards in the study of protein translocation and secretion. Just as intriguing was the race to identify SRP, as two teams — one based in New York, the other in Heidelberg — took up the quest and scored complementary victories.
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Acknowledgements
The author is grateful to G. Blobel, B. Dobberstein, L. Gerace, V. Lingappa, D. Meyer, K. Mostov, K. Simons, P. Walter and G. Warren for sharing their memories of the events described here, to B. Dobberstein for providing a representation of the salt-wash data shown in Fig. 1, to D. and E. Meyer for Fig. 4, and to N. Matlin for critically reading the manuscript.
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Matlin, K. The strange case of the signal recognition particle. Nat Rev Mol Cell Biol 3, 538–542 (2002). https://doi.org/10.1038/nrm857
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DOI: https://doi.org/10.1038/nrm857