The mode of Crohn's disease inheritance is unclear and might be explained by unidentified risk loci. Hong et al. performed deep sequencing of samples from 500 patients with Crohn's disease and 1,000 healthy control individuals in the Republic of Korea focusing on 131 genes associated with the disease. The team found three previously known variants, but also identified eight novel variants that might represent additional risk loci for Crohn's disease in these patients.
References
Hong, S. N. et al. Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants. Gut 10.1136/gutjnl-2014-308617
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GWAS reveals eight novel variants associated with an increased risk of Crohn's disease. Nat Rev Gastroenterol Hepatol 12, 250 (2015). https://doi.org/10.1038/nrgastro.2015.64
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DOI: https://doi.org/10.1038/nrgastro.2015.64
