In the first double-blind, proof-of-concept study for faecal transplant to treat ulcerative colitis, patients received a transplant from either themselves or from healthy donors. No difference was observed in clinical remission of colitis between the two groups. Interestingly, patients who responded to treatment had altered faecal microbiota composition compared with nonresponders. The authors believe this result warrants further investigation.
References
Rossen, N. G. et al. Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology 10.1053/j.gastro.2015.03.045
Rights and permissions
About this article
Cite this article
Faecal transplant from donors no more effective than autologous transplant for treating ulcerative colitis. Nat Rev Gastroenterol Hepatol 12, 250 (2015). https://doi.org/10.1038/nrgastro.2015.62
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2015.62
