Sympathetic and parasympathetic hepatic innervation actively influences VLDL triglyceride secretion. In a model of obese Zucker rats, researchers surgically denervated the sympathetic or parasympathetic hepatic nerve. Removing sympathetic innervation reduced VLDL triglyceride secretion and plasma concentrations after 6 weeks, whereas parasympathetic denervation increased plasma levels of total cholesterol, suggesting a novel treatment target.
References
Bruinstroop, E. et al. Hepatic denervation and dyslipidemia in obese Zucker (fa/fa) rats. Int. J. Obes. (Lond.) 10.1038/ijo.2015.122
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Regulation of lipid profiles by the autonomic nervous system. Nat Rev Gastroenterol Hepatol 12, 488 (2015). https://doi.org/10.1038/nrgastro.2015.141
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DOI: https://doi.org/10.1038/nrgastro.2015.141
