New data might explain the observation that gastric cancer patients infected with Helicobacter pylori have an improved response to chemotherapy and better overall prognosis than those who aren't infected. Zhou et al. found H. pylori infection downregulates expression of miR-141 and that KEAP1 is a direct target of miR-141. In gastric cancer cells, cisplatin sensitivity was enhanced by miR-141 knockdown and by KEAP1 overexpression; cisplatin resistance was enhanced by miR-14 overexpression and by KEAP1 downregulation. In H. pylori-positive tissue samples KEAP1 was upregulated.
References
Zhou, X. et al. Helicobacter pylori modulates cisplatin sensitivity in gastric cancer by down-regulating miR-141 expression. Helicobacter 10.1111/hel.12120
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Helicobacter pylori infection improves response to cisplatin. Nat Rev Gastroenterol Hepatol 11, 268 (2014). https://doi.org/10.1038/nrgastro.2014.56
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DOI: https://doi.org/10.1038/nrgastro.2014.56