Several key studies published in 2014 have shed light on the pathogenesis of IBD by investigating the molecular mechanisms controlling mucosal homeostasis and intestinal barrier function. These studies revealed that alterations of intestinal homeostasis drive chronic intestinal inflammation. Here, we describe these findings and discuss future directions for translational research in IBD.
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Atreya, R., Neurath, M. Molecular pathways controlling barrier function in IBD. Nat Rev Gastroenterol Hepatol 12, 67–68 (2015). https://doi.org/10.1038/nrgastro.2014.201
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DOI: https://doi.org/10.1038/nrgastro.2014.201
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